EOSS Industries, Kanzler Verfahrenstechnik and the Rieckermann Group pool their strengths to implement their shared vision of circular economy; BDI’s technological leadership makes an important contribution. As part of this agreement, EOSS Industries also absorbs the shares in BDI Holding and BDI-BioLife Science. The BDI Group currently employs about 140 members of staff. The parties have agreed not to disclose the acquisition price.

Headquartered in Graz, BDI-BioEnergy International is an internationally operating niche player specializing in the development of chemical and biochemical procedures, the implementation of product plants for biodiesel and biogas as well as plants for the processing of pyrolysis oil and depolymerization. BDI-BioLife Science, based in Hartberg, is the number one manufacturer of natural astaxanthin in Central Europe and active in the life science industry.

By combining entrepreneurial leadership with innovational strength and the benefits of a strong participation holding, EOSS Industries has acquired renown as a pioneer in the strategic development and support of medium-sized companies. Together with EOSS Industries, the internationally operating industrial solutions providers Kanzler Verfahrenstechnik and the Rieckermann Group engage in the takeover of BDI-BioEnergy International. The Rieckermann Group, invests via their in-house corporate investment arm, JR New Horizons GmbH.

“We are delighted at this partnership with BDI and the additional interest in BDI-BioEnergy International by Kanzler Verfahrenstechnik and Rieckermann,” explains EOSS manager David Niederl, who is going to reinforce the executive board of the BDI Group. “Together, we will be able to raise our commitment to sustainable energy to a completely new level.” For Kanzler Verfahrenstechnik and Rieckermann, this trade also marks a milestone against the background of the already 12-year long successful cooperation of both companies in the complex industrial plant manufacturing in Asia. “This is a golden opportunity to promote the expansion of an innovative technological offer, namely in a key area for sustainable economy worldwide,” Florian Kanzler, CEO of Kanzler Verfahrenstechnik, and Oliver Raab, Head of Industry Chemical & Energy at Rieckermann Group, are in agreement.

BDI is equally enthusiastic: “The pooling of strengths perfectly fits our long-term vision and will further enhance our position as innovative pioneer in the fields of biogas, biofuels and chemical plastic recycling. To implement our vision regarding the red diamond, we have found the perfect strategic partner with EOSS and its subsidiary, Sanochemia. In this new constellation and as quality, technology and innovation leader, we will be an appealing employer headquartered in Styria,” says Kurt Ternegg, CEO of the BDI Group.

“The takeover by these family-owned companies ensures a sustainable continuation of our lifework. We consider ourselves fortunate to have found such strong partners for the BDI Group,” assert Wilhelm Hammer and Helmut Gössler, the founders of the BDI Group.

About EOSS Industries

EOSS Industries is an innovation-oriented industry and technology corporation targeting the long-term development of its companies. As a medium-sized enterprise group, the participations of EOSS generate approximately 200 million euro across the globe, export to more than 60 countries worldwide and employ about 500 members of staff. Defined goal is to turn every EOSS company into a hidden champion of its branch. Currently, the EOSS Group focuses on the subject areas life science, energy & infrastructure and future commerce.

About Kanzler Verfahrenstechnik

Kanzler Verfahrenstechnik (KVT) develops and implements industrial plants based on the concepts of green chemistry and closing the cycle. Renewable raw materials, by-products from industrial processes or waste flows serve as basic materials for the production of worthful chemicals, for the closing of material cycles as well as for the reuse of industrial waste. The technology portfolio contains solutions for the manufacture of chemical products based on regrowing raw materials, environmental technologies in the field of waste water and waste gas treatment and the production and the recovery of sulfuric acid from sulfurous waste gas, sulfur or spent acid. The family-owned business is internationally active and has about 160 employees in Austria and Germany.

About the Rieckermann Group

Rieckermann Group is a family-owned corporate group offering complex industrial production and process solutions for various industrial areas in Asia and the Middle East as contractor and technology provider. Over 130 years of corporate history, Rieckermann Group has built up a reputation in its core markets – especially regarding integrated customized process solutions which the company maintains on a long-term basis thanks to its local technical service. Furthermore, the broad-ranging offer portfolio includes consultation services, engineering and project management as well as the selection, financing and delivery of process technologies by leading international suppliers and drivers of innovation. Globally, over 750 employees at 24 locations in 17 countries contribute to the success of the Rieckermann Group.

JR New Horizons is an independent investment branch within the Rieckermann Group promoting innovations and financing important key projects through strategic investments, participations and transformation support to carry the vision of a holistic solutions provider for industrial productions focusing on sustainable process technologies into effect.

About the BDI Group and its subsidiaries, BDI-BioEnergy International and BDI-BioLife Science

BDI-BioEnergy International is market leader in the construction of biodiesel plants, additionally offering environmentally friendly procedural solutions for the processing of waste and pyrolysis oils as well as fermentation technologies developed in-house for biogas plants. The service portfolio ranges from contract research and process development to engineering and scale-up services to customer service.

BDI-BioLife Science, based in Hartberg, specializes in the production of high-quality algal material for the life-science area and is number one in the production of natural astaxanthin in Central Europe. With its closed algae cultivation method developed in-house, the company ensures a constant manufacture of natural astaxanthin. The production infrastructure safeguards year-round product availability and constant high quality.

The BDI Group currently employs about 140 members of staff.

Der Beitrag A strategic partnership for a sustainable future erschien zuerst auf BDI-BioLife Science.

Astaxanthin: A natural
Booster for better fertility

Abstract

Astaxanthin is a natural active ingredient from the algae Haematococcus pluvialis and belongs to the carotenoids. The molecule has 40 carbon atoms and a large number of conjugated double bonds. This enables it to transfer electrons particularly efficiently and thus neutralize free radicals.

Due to its special chain length, the structure of its end groups and the number of methyl groups, it has a strong antioxidant effect without becoming a radical itself and being pro-oxidative.

(1-4) Antioxidants such as astaxanthin have very good anti-inflammatory properties and can therefore support the immune system. Numerous studies have confirmed a positive effect of astaxanthin supplementation on the activity of natural killer cells in the body, oxidative balance and inflammation. (5,6) (7)

Micronutrients: Essential for
Health and well-being

Vitamins and trace elements, so-called micronutrients, are essential for a functioning organism and a healthy lifestyle. Optimization of the diet and supplementation with micronutrients, incl. Antioxidants such as astaxanthin are particularly recommended in phases of life such as growth, everyday stress and especially during pregnancy.

Optimal support: omega-3 fatty acids and astaxanthin before and during pregnancy

It is important to get enough nutrients and vitamins before pregnancy. Zinc and B vitamins can increase fertility and promote healthy development and birth.

During pregnancy, women have an increased need for vitamins and nutrients. Omega-3 fatty acids help the development of the baby’s eyes and brain. It is advisable to take them in order to give the child the best possible support.

Maximum support during pregnancy:
Iron and B vitamins for blood formation

The mother’s blood volume rises sharply. Iron and B vitamins help with the production of new blood cells, prevent tiredness and support the thyroid gland. Folic acid and iodine reduce the risk of neural tube defects and promote nerve development.

Astaxanthin: For healthy baby development

During pregnancy, the production of ROS increases, partly due to the functioning of the placenta.

The placenta performs important functions for the baby, such as …

• Food,
• Detoxification and
• Oxygen supply in the first few weeks.

The resulting oxidative stress is associated with the risk of spontaneous abortion and other complications.

Astaxanthin: the natural antioxidant
for healthy pregnancies

Astaxanthin is a powerful antioxidant that can increase the chances of a healthy pregnancy, even at an advanced age.

Studies have already shown the positive influence and safe effect of carotenoids such as astaxanthin during pregnancy and breastfeeding. (8)

Male fertility at risk?
How oxidative stress impairs sperm quality

It can also be difficult for men to reconcile child planning and a healthy lifestyle. Oxidative stress has a negative effect on male fertility. Sperm have a special membrane structure that enables them to move and fertilize. Many unsaturated fatty acids in the sperm envelope make sperm cells susceptible to a lot of ROS and stress through oxidation.

The risk of oxidative stress for sperm:
Why protection against free radicals is important

Since sperm have little protection against free radicals, oxidative stress can lead to a decrease in viability and motility as well as to a change in the overall metabolism of the sperm. (9)

Oxidative stress also causes damage to DNA. Analyses between 1971 and 2011 show a significant decline of over 50% in the sperm count of men from industrialized countries. (10)

Randomized study proves: Astaxanthin promotes fertility in men and women

In a randomized, placebo-controlled double-blind study on supplementation with astaxanthin, an increase in sperm concentration and quality was demonstrated.

In addition, the partners in the astaxanthin group who consumed 16 mg of astaxanthin per day had significantly more pregnancies during the study period. Over half (54.5%) of the partners in the astaxanthin group became pregnant during the study period, compared with only 10.5% in the placebo group. (9)

In addition to increasing sperm concentration, astaxanthin could contribute to an increase in fertility by improving sperm capacitation.

Only through capacitation, the biochemical remodelling process of the sperm cell, is it possible for it to fertilize an egg cell. In vitro studieshave shown that astaxanthin can improve this process with its positive influence on the oxidative balance. (12, 13)

Animal studies prove it: Astaxanthin increases sperm count and motility!

Furthermore, animal studies with typical risk factors for poor fertility showed positive effects in the test group with astaxanthin supplementation: For example, sperm cells from overweight rats fed astaxanthin had a higher sperm count, motility and viability than the sperm of the comparison group. (14)

Another animal study showed that astaxanthin can minimize the harmful effects of nicotine on fertility. In this case, the astaxanthin group also showed increased sperm count, motility and viability compared to the control groups. (15)

Astaxanthin has been researched and administered in horse breeding since the 1990s in order to achieve higher fertility performance and profitability. By improving the motility and protection of sperm, astaxanthin has a positive effect on fertility. (11)

Summary: Astaxanthin boosts male fertility and increases the chance of pregnancy

By reducing ROS, astaxanthin can improve male fertility and thus increase the likelihood of pregnancy. If astaxanthin is combined with other nutrients and vitamins, this effect could be further enhanced. Zinc, selenium, vitamin E and B improve sperm production and motility. This increases the chances of successful family planning.

___________________________

Literature

1. Pizzino, G. et al. Oxidative Stress: Harms and Benefits for Human Health. Oxid. Med. Cell. Longev. 2017, (2017).
2. Nishida, Y., Yamashita, E. & Miki, W. Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants against Singlet Oxygen Using Chemiluminescence Detection System. Carotenoid Sci. 11, 16–20 (2007).
3. Régnier, P. et al. Astaxanthin from Haematococcus pluvialis prevents oxidative stress on human endothelial cells without toxicity. Mar. Drugs 13, 2857–2874 (2015).
4. Martin, H. D. et al. Chemistry of carotenoid oxidation and free radical reactions. Pure Appl. Chem. 71, 2253–2262 (1999).
5. Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L. & Chew, B. P. Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans. Nutr. Metab. (2010) doi:10.1186/1743-7075-7-18.
6. Baralic, I. et al. Effect of Astaxanthin Supplementation on Salivary IgA, Oxidative Stress, and Inflammation in Young Soccer Players. Evidence-based Complement. Altern. Med. 2015, (2015).
7. Donoso, A., González-Durán, J., Muñoz, A. A., González, P. A. & Agurto-Muñoz, C. “Therapeutic uses of natural astaxanthin: An evidence-based review focused on human clinical trials”. Pharmacol. Res. 166, (2021).
8. Zielińska, M. A., Wesołowska, A., Pawlus, B. & Hamułka, J. Health effects of carotenoids during pregnancy and lactation. Nutrients 9, 1–25 (2017).
9. Comhaire, F. H., El Garem, Y., Mahmoud, A., Eertmans, F. & Schoonjans, F. Combined conventional/antioxidant ‘Astaxanthin’ treatment for male infertility: A double blind, randomized trial. Asian J. Androl. 7, 257–262 (2005).
10. Levine, H. et al. Temporal trends in sperm count: A systematic review and meta-regression analysis. Hum. Reprod. Update 23, 646–659 (2017).
11. Heczko, K. Einfluß der Zufütterung von karotinoidem Astaxanthin auf die Spermaqualität und die Fruchtbarkeit von Warmbluthengsten zur Erlangung des Grades einer ( Dr . med . vet .) durch die Tierärztliche Hochschule Hannover Vorgelegt von Kristin Hildegard Heczko au. (Tierärztliche Hochschule Hannover, 2004).
12. Donà, G. et al. Effect of astaxanthin on human sperm capacitation. Mar. Drugs 11, 1909–1919 (2013).
13. Andrisani, A. et al. Astaxanthin improves human sperm capacitation by inducing lyn displacement and activation. Mar. Drugs 13, 5533–5551 (2015).
14. Mortazavi, M., Salehi, I., Alizadeh, Z., Vahabian, M. & Roushandeh, A. M. Protective effects of antioxidants on sperm parameters and seminiferous tubules epithelium in high fat-fed rats. J. Reprod. Infertil. 15, 22–28 (2014).
15. Ashrafizadeh, M. & Ahmadi, Z. Effect of Astaxanthin Treatment on the Sperm Quality of the Mice Treated with Nicotine. Rev. Clin. Med. 6, 1–5 (2019).

Der Beitrag Astaxanthin for fertility and pregnancy erschien zuerst auf BDI-BioLife Science.

Abstract

As life expectancy continues to rise, healthy ageing is on everyone’s lips. We strive for eternal youth by maintaining general physical health, wellbeing and the natural functionality of our skin to avoid visible signs of age. A Sisyphean task because we cannot stop the ageing process of our body and skin, but we can positively influence and delay it through preventive strategies. Antioxidants play a very important role to inhibit ageing. The most effective antioxidant is astaxanthin which, due to its biological potential of cell protection, is considered the strongest natural antioxidant. Therefore, it is the perfect choice as anti-ageing ingredient since it acts as a protective shield to reduce environmental stress and skin ageing. Numerous clinical studies have already revealed its positive effects on skin ageing processes due to its unique molecular structure. BDI-BioLife Science can prove the effects of astaxanthin with in-house human clinical studies in the field of cosmetics with its branded active ingredient, an oleoresin with an astaxanthin content of 5%.

As protective shield, the skin is constantly exposed to external environmental influences and stress caused by internal factors such as athletic exertion and external factors such as UV rays. To maintain and support the skin as a protective barrier, numerous active ingredients are used in cosmetics. As part of these active ingredients, antioxidants can neutralise stress factors in the skin and can offer protection against those toxic substances. There is a variety of antioxidants such as vitamin C and coenzyme Q10, but natural astaxanthin has proven to be nature’s most powerful antioxidant yet discovered, with properties that by far surpass all its peers. In direct comparison, astaxanthin is 6,000 times more powerful than vitamin C and 100 times more powerful than vitamin E by neutralising singlet oxygen.[1]

Astaxanthin – the red diamond among antioxidants

Astaxanthin belongs to the carotenoid family, more precisely to the xanthophylls. In nature, the red pigment can be found in photosynthetic organisms such as bacteria, algae and yeasts. The highest concentrations of natural astaxanthin can be obtained from the freshwater microalga Haematococcus pluvialis. Due to its enormous antioxidant power, astaxanthin is considered the red diamond among radical scavengers and has been proven to be significantly more efficient at counteracting reactive oxygen species (ROS) compared to other antioxidants. Thanks to its unique molecular structure, it is non-pro-oxidative.[2] Astaxanthin is not only an incredibly powerful antioxidant, but also unique in terms of how it works in our bodies because it spans the cell membrane to protect the entire cell. The length and shape of an astaxanthin molecule allows it to span the cell membrane, having one end of the molecule in the lipid-soluble part of the cell and the other end in the water-soluble part (Figure 1).

Figure 1: Astaxanthin spans the cell membrane in a transmembran orientation.

This makes astaxanthin distinctively characteristic of being able to protect the entire cell. Astaxanthin has been found capable of flowing throughout the entire body into the bloodstream, to the muscle tissue and skin as well as into various critical organs. This double feature of running through the body and being able to protect the entire cell makes astaxanthin a super-effective antioxidant and an anti-inflammatory agent for humans.[3]

In several human studies, astaxanthin has improved overall skin health and counteracted skin ageing by providing comprehensive protection against ROS-related damage. Positive effects on the human skin have been shown particularly regarding wrinkle depth, elasticity, moisture, age spots and skin texture. Astaxanthin improves skin elasticity by strengthening the collagen layer and revitalises photoaged skin by getting rid of free radicals in all skin layers. Moreover, it positively affects skin health both through supplemental nutrition and topical applications in cosmetics. To increase efficacy, these applications can also be combined.[4]

Skin ageing – Principle of cause and effect

Our skin is the outermost barrier against environmental impacts. Whenever the skin is exposed to reactive oxygen species (ROS) and free radicals, oxidative stress is occurring subsequently. Oxidative stress plays a crucial role in human skin damage. When singlet oxygen attacks cell membranes, it activates enzymes that lead to cell death, changes of skin appearance and the onset of active skin ageing processes. Singlet oxygen can also interfere with the DNA, triggering a series of cell processes that ultimately lead to inflammation.[5] Many age-related conditions are caused by increased levels of proinflammatory cytokines and cellular senescence. Due to increased environmental influences in the 21st century, a continuous low level of chronic inflammation increases leading to a gradual erosion of normal cell structure and functioning, which results in enhancing a slow but progressive ageing process also known as inflammageing. When skin structure and function decline, the skin becomes more sensitive and highly vulnerable to oxidative damage.[6]

A healthy individual normally has a certain level of antioxidants as natural defence mechanism to prevent free radical formation, maintain oxidative balance and protect the skin against oxidative damage and associated inflammations. However, through ongoing high exposure to ROS in our daily life, not only the barrier function of the skin deteriorates, but also the metabolic activity of cells and the intrinsic antioxidant level decrease, favouring intracellular oxidative stress and subsequent inflammatory reactions. High daily exposure to free radicals and the decreasing ability to protect ourselves from the formation and effects of these toxic reactive substances create a need to support our bodies in counteracting oxidative stress and subsequent cellular damage. The use of antioxidants in cosmetic formulations is one way to counteract the environmental effects on our skin.

Astaxanthin and its biological cell protection properties

Reactive oxygen species, responsible for extrinsic premature skin ageing, have increasingly aroused interest by the cosmetic industry as the human skin is permanently exposed to a pro-oxidative environment. These ROS are considered toxic derivatives of oxygen and cause skin damage as soon as the organism’s defence system is no longer capable of inactivating most ROS. Cells have a natural stress level (6.25% neg. control in Figure 2) that increases with exposure to ROS. Enhanced intracellular stress accelerates cellular ageing and promotes age-related skin changes such as wrinkles and age spots. In an in-vitro study, the influence of oleoresin with a content of 5% astaxanthin regarding antioxidant efficacy against ROS was investigated. To determine the potential antioxidant effect, primary human keratinocytes were treated with 0.01%, 0.05% and 0.1% oleoresin with a content of 5% astaxanthin for 24 hours. After incubation time, 10µM of DCFH-D_A (chemical used to detect the presence of oxidative molecules) were applied for one hour. Subsequently, 500µM H₂O₂ were added to induce oxygen radicals (ROS). As a check, untreated cells without induced ROS (negative reference) and unprotected ROS-induced (positive) cells were used. As shown in Figure 2, the active ingredient is able to strongly reduce oxidative stress in a dose-dependent manner.[7]

Figure 2: Cell stress reduction by oleoresin with a content of 5% astaxanthin in different concentrations dissolved in olive oil 24 hours after ROS induction by H₂O₂

Astaxanthin and its anti-ageing properties

Skin dryness, deep wrinkling, laxity, increasing transepidermal water loss (TEWL) and epidermal barrier disorders are typical characteristics of aged skin. Astaxanthin, derived from the microalga Haematococcus pluvialis, has proven several positive effects on the human skin, especially on wrinkle depth, elasticity, moisture, age spots and skin texture.

For an in-vivo study, 20 healthy female test subjects between 24 and 56 years of age (Ø 34) with normal skin were recruited. All tests were performed within one day and conducted on the inner side of the forearms. Test substances 0.05% ASTACOS® OL50 diluted in organic jojoba oil and 100% organic jojoba oil were tested.

To determine skin hydration, the Corneometer MPA 5 CPU was used. The skin roughness (firmness) was measured using the Frictiometer MPA 5 CPU. Results were evaluated using descriptive statistics and the Wilcoxon Rank Test (statistical model to ensure reliable results). The test subjects were instructed not to use any topical preparations on the test areas within a period of seven days before the study until the completion of the study. When the study started, the parameters were determined in the relevant test areas as a negative control sample.

Then the test products, 0.05% ASTACOS® OL50 diluted in jojoba oil and 100% jojoba oil, were applied to the corresponding test areas. After 2 hours of incubation time, the parameters of skin hydration and skin roughness (firmness) were measured again in the test zones. Even after a single application of 0.05% ASTACOS® OL50 diluted in jojoba oil, the skin roughness (firmness) and the hydration level of the skin had improved, as shown in Figure 3.[8]

Figure 3: Change in skin hydration and skin roughness after application of 100% jojoba oil and and jojoba oil with 0.5% ASTACOS® OL50 after 2h incubation period

In another in-vivo efficacy study with a serum containing 0.05% of the active ingredient, the effectiveness of astaxanthin was confirmed in an application test that spanned over 4 weeks. A total of 25 female and male volunteers aged between 35 and 72 years (Ø 52.9 years; skin profile sensitive to atopic skin) participated in this in-vivo study and were supervised and monitored by a dermatologist. All participating subjects were instructed to use only the investigational product once a day and to maintain their usual skincare routine. The subjects reported a significant reduction in wrinkles and lines as well as a reduction in age spots and pigmentation. It is also noteworthy that over 60% of the participants described their skin as finer after completion of the study. [9][10]

Conclusion

Numerous research studies have led to the conclusion that astaxanthin can improve overall health of the skin and counteract skin ageing and inflammatory processes. Due to its multiple properties, astaxanthin acts exactly where it is needed and penetrates deep into the skin layers. In particular, protection against skin ageing as well as strong anti-ageing effects can be highlighted. Astaxanthin from microalgae is perfect for the use in leave-on products. When being extracted as oleoresin, the power antioxidant can be ideally incorporated into a wide variety of formulations such as facial applications, pretreatment and cell protection products, as it protects our skin against photoageing and supports anti-ageing. BDI-BioLife Science GmbH has developed a special COSMOS-certified and NATRUE-approved active ingredient to bring this unique antioxidant into cosmetic formulations.

ASTACOS® OL50 (Figure 4) is a vegan, animal testing-free ingredient, derived from the microalga Haematococcus pluvialis, containing 5% of natural astaxanthin. It has already shown its potential to neutralise free radicals in several in-vivo and in-vitro studies and has proven to be an efficient active ingredient for anti-ageing properties. With its in-house astaxanthin competence centre, BDI-BioLife Science supports its customers with expertise in processing and formulating ASTACOS® OL50, confirmed by various frame formulations and scientific dossiers.

Figure 4: ASTACOS® OL50, oleoresin with an astaxanthin content of 5%

Read the article now in the SOFW Magazine

[1] Y. Nishida, E. Yamashita, and W. Miki, “Quenching Activities of Common Hydrophilic and Lipophilic Antioxidants against Singlet Oxygen Using Chemiluminescence Detection System,” Carotenoid Sci., vol. 11, no. December, pp. 16–20, 2007.

[2] R. R. Ambati, P. S. Moi, S. Ravi, and R. G. Aswathanarayana, “Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications – A review,” Mar. Drugs, vol. 12, pp. 128–152, 2014.

[3] B. Capelli, S. Talbott, and L. Ding, “Astaxanthin sources: Suitability for human health and nutrition,” Funct. Foods Heal. Dis., vol. 9, no. 6, pp. 430–445, 2019.

[4] K. Tominaga, N. Hongo, M. Karato, and E. Yamashita, “Cosmetic benefits of astaxanthin on human subjects,” Acta Biochim. Pol., vol. 59, no. 1, pp. 43–47, 2012.

[5] K. Scharffetter-Kochanek et al., “Photoaging of the skin from phenotype to mechanisms,” Exp. Gerontol., vol. 35, no. 3, pp. 307–316, 2000.

[6] S. M. Pilkington, S. Bulfone-Paus, C. E. M. Griffiths, and R. E. B. Watson, “Inflammaging and the Skin,” J. Invest. Dermatol., vol. 141, no. 4, pp. 1087–1095, 2021.

[7] D. G.-R. institute for reliable Results, “Physiological/Histological in vitro Expertise,” no. March, 2021.

[8] Dr. Hauck R&D GmbH, “Efficacy Test in vivo conducted with ASTACOS OL50 (Cosmetic Study),” 2021.

[9] D. G. K. (Institute for E. D. at Witten/Herdecke, “REPORT über einen Anwendungs- und Verträglichkeitstest des Prüfpräparates,” 2021.

[10] T. Seki, H. Sueki, H. Kohno, and K. Suganuma, “Effects of astaxanthin from Haematococcus pluvialis on human skin,” pp. 98–103, 2001.

Der Beitrag Austrian natural astaxanthin – a unique active ingredient for biological cell protection erschien zuerst auf BDI-BioLife Science.

We are pleased to share some wonderful news with you. Trapeze Associates has been appointed as the exclusive agent and distributor for BDI-BioLife Science in the dynamic markets of Australia and New Zealand. 🇦🇺

Here’s a glimpse of the product range that will be available:
– ASTAFIT® OL100
– ASTAFIT® OL50
– ASTAFIT® CWD25
– ASTAFIT® CWD50
– ASTAFIT® 1% Astaxanthin mit NovaSOL
– ASTACOS® OL50

Starting from today, 1st of September 2023, Trapeze Associates will take on the exclusive responsibility of distributing these remarkable products in Australia and New Zealand.

The red diamond expands💎

We are looking forward to a strong and successful long-term partnership.

Stay tuned for more updates and exciting developments as we embark on this exciting journey together!

Find out more about Trapeze Associates

Der Beitrag We are growing! erschien zuerst auf BDI-BioLife Science.

Astaxanthin is now EU-approved for children aged three and above!

Thanks to its unique antioxidative and anti-inflammatory properties as well as its ability to overcome the blood-brain and blood-retina barrier, astaxanthin takes effect where large amounts of free radicals origin and protects the organism thoroughly against oxidative damage. Now children can also benefit from the positive effects of natural astaxanthin.

Here are the recommended daily dosages:
Children (3-10): 2.3 mg of Astaxanthin per day.
Adolescents (10 -14): 5.7 mg of Astaxanthin per day.
Adults (Older than 14): 8 mg of Astaxanthin per day.

In our ASTAFIT®, the antioxidative effect of the red diamond is delivered in a wide range of dosage forms that are perfect for further processing in capsules, health drinks, gummies and many other applications.

Any questions? Feel free to contact us.

Der Beitrag Approval of astaxanthin for children erschien zuerst auf BDI-BioLife Science.

We are excited to announce that our new website has received the silver WEBSTAR award! ⭐️
For participation in the Webstar Award, our website was analysed with three tools in order to judge its performance, security, and SEO.

The result: a score so high that we achieved the silver status!

We want to thank everyone who contributed to the exciting journey to our new website.

Der Beitrag We won the WEBSTAR Award erschien zuerst auf BDI-BioLife Science.

We at BDI-BioLife Science are proud to announce that our astaxanthin products adhere to this quality standard, with the FDA having issued the following products with the self-affirmed GRAS (Generally Recognized as Safe) status:

• ASTAFIT® OL100
• ASTAFIT® OL50
• ASTAFIT® CWD25
• ASTAFIT® CWD50

These products are thereby cleared for use in various food categories, including but not limited to beverages, cereal products, milk products, processed fruit and vegetable juices, sports drinks, hard and soft candy, chewing gums and baking goods.

This advancement opens up a whole new world of possibilities for our products on the American market!

Discover products with ASTAFIT®!

Der Beitrag A big step with small algae erschien zuerst auf BDI-BioLife Science.

The most important annual fair for food supplements in Switzerland – thousands of experts from more than 100 countries meet in Geneva for Vitafoods Europe.

BDI-BioLife Science took part in this unique event again this year with a stand and a team of experts.

Inspiring conversations with passionate nutraceutical enthusiasts, innovative presentations, the latest trends in the industry and our red diamond smack dab in the middle!

See you again next year!

Der Beitrag Vitafoods Europe 2023 – the nutraceuticals event of the year erschien zuerst auf BDI-BioLife Science.

Der Beitrag Pursuing energy independence erschien zuerst auf BDI-BioLife Science.

Recap in-cosmetics global in Barcelona 2023: it was an unforgettable experience, an event full of valuable impressions and conversations with highly interesting contacts.

We are very proud to announce that our ASTACOS® won the third place at BSB Innovation Award 2023 in the category „natural products/raw materials actives“, which is an important step for our successful journey.

Thank you all for joining us, special thanks to our great partner RAHN-Group for having us at their booth.

Stay tuned for what’s yet to come!

Der Beitrag In-cosmetics Global 2023 – the cosmetics highlight of the year erschien zuerst auf BDI-BioLife Science.

As the largest human organ, the skin acts as main protective shield against harmful environmental influences. We often forgotten that even the air contains dangerous substances. The pollutants contained in the air can be absorbed by the skin and trigger free radicals that cause serious damage in the skin’s structure. This is the reason why the concept of anti-pollution cosmetics is gaining more and more importance. Their purpose is to provide the skin with protection against all negative environmental influences, such as smog or radiation. One possibility is to generate protection indirectly, using several raw materials from the segment of antioxidants. However, if you want to design a highly modern and extremely effective formulation, you should not forget the trend-setting vegan ingredient astaxanthin. The reddish pigment from the carotenoid family is extracted from the alga Haematococcus pluvialis and considered the strongest naturally occurring antioxidant. To minimise long-term skin damage associated with pollution, astaxanthin can be used as a second-line protection. Its anti-inflammatory activity has been known for a long time and has been confirmed by numerous studies. Especially for cosmetic products, BDI-BioLife Science has developed its own raw material containing 5% of astaxanthin. The properties of the red diamond have been substantiated by in vivo and in vitro proof of efficacy. While its effect against blue light-induced stress has already been proven in preliminary studies, the current research takes a closer look at the issue of blue light.

Natural and highly effective ingredients are increasingly becoming important; especially in the field of anti-pollution, the cosmetics industry is constantly looking for new solutions. One possible raw material could be the astaxanthin-containing antioxidant AstaCos® OL50. This Cosmos-certified active ingredient combines the astaxanthin-containing algae extract Haematoccocus pluvialis with high-quality organic jojoba oil and is standardised to an astaxanthin content of 5%. Due to its enormous antioxidant capacity and its ability to neutralise free radicals, astaxanthin is recommended for use in anti-pollution cosmetics. In this article, you will find out why anti-pollution is more than just a trend and why astaxanthin is a possible solution.

Protection from pollutants – more than a trend

In the past, the issue of environmental pollution has mainly been important in Asia, with its massive cities and metropolitan air problems leading to smog. However, for a considerable time, pollution has also played a significant role in the western world, especially in Europe and the US. Hence, more and more cosmetic products are now addressing this topic and have successfully been marketed.[1] This fact is underlined by a study showing that in the first quarter of 2016, more than 70% of new skincare products worldwide contained an anti-pollution claim.[2] Air pollution is now an omnipresent environmental and even health problem affecting the whole world.

It is important to differentiate between natural and human-made air pollution. Natural pollution from fire or volcanic eruptions is a minor contributor, while most of the pollution is man-made, for example due to the use of fossil fuels to generate heat or energy, or due to agricultural activities. Air pollution can be divided into primary and secondary pollutants.[3] Primary pollutants are emitted directly from pollution sources and include, for example, gases (CO2, SO2 and NO2), low molecular weight hydrocarbons, even heavy metals (e.g., lead) as well as particulate matter (PM). Secondary pollutants are formed in the atmosphere through chemical and photochemical reactions with primary pollutants, such as ozone.[1,3] Figure 1 gives an overview of pollutants in the environment.

Figure 1: Environmental pollutants.[4]

As diverse environmental pollution is, as complex is dealing with this particular, mostly invisible challenge. The first step in combating pollution is often an adequate cleansing of the skin to remove deposited chemicals. As a first line of defence against unwanted environmental influences, the epidermis can be isolated, which can be done when there is a cohesive and non-occlusive film on the surface of the skin. Thus, direct contact with atmospheric pollutants can be avoided, especially when film-forming raw materials of synthetic or natural nature are used. Another strategy is to incorporate antioxidants into the anti-pollution formulation to neutralise free radicals or stimulate the antioxidant defence system for protection against the damage caused by free radicals.[3] Therefore, the second line defence works indirectly against pollutants, but directly in the body to stop negative processes.

The red diamond amongst radical scavengers

Astaxanthin belongs to the group of carotenoids, and more precisely, to the xanthophylls and is considered the strongest natural antioxidant. Several natural organisms are able to produce astaxanthin, such as bacteria, algae and yeasts, but the highest concentrations of natural astaxanthin can be derived from the freshwater microalga Haematococcus pluvialis. Due to its enormous antioxidant effect, astaxanthin is called the red diamond among radical scavengers and has been proven to counteract reactive oxygen species (ROS) much more efficiently compared to other antioxidants. Thanks to its unique molecular structure, it is non-pro-oxidative.[5]

The enormous antioxidant capacity of astaxanthin is due to its unique mechanism of action in our body. The length and shape of an astaxanthin molecule allow it to span the cell membrane, with one end of the molecule in the lipid-soluble part of the cell and the other end in the water-soluble part. Therefore, astaxanthin is able to protect the entire cell. Numerous studies have concluded that astaxanthin can improve the overall skin health and counteract skin ageing and inflammatory processes (Figure 2). Due to its multiple properties, astaxanthin works exactly where it is needed and penetrates deep into the skin layers. Especially the biological cell protection and the strong anti-ageing effect can be highlighted.

Figure 2: Astaxanthin acts against oxidative stress and ROS.

Blue light radiation as part of the pollution

Using film-forming agents as a shelter can only protect against physical influences such as particular matter or chemicals, but not against harmful radiation (e.g., UV, infrared or blue light radiation).[6] Especially the combination of daily radiation and the oxygen-rich atmosphere in which we live generates stress and unwanted processes in our skin.[7] Damage caused by sunlight can lead to wrinkling, dry skin and general pigmentation disorders. In the worst case, this damage can even lead to skin cancer. Sunlight consists of many fractions and can be classified by wavelength and energy level which penetrate the skin into different depths (Figure 3).

Figure 3: Classification of light by penetration depth.[10]

The UV component of sunlight is absorbed by the skin, which accelerates the formation of reactive oxygen species (ROS) in the skin.[8] Long-term and combined irradiation of human skin with UVB and UVA leads to reduced skin renewal potential and to structural damage. By penetrating deep into the skin down to the dermis, the rays destroy collagen and elastin which enable the skin’s firmness and elasticity.[9] Another type of radiation is infrared radiation (IR) which includes wavelengths from 700nm to 1mm. Within this group, a distinction can be made between IR-A (700 to 1400nm), IR-B (1400 to 3000nm) and IR-C (3000nm to 1mm). Almost half of the solar energy that reaches the earth’s surface is in the IR range, so, this type of radiation has significant biological effects on the human skin.[11, 12] Visible light (VL) covers the spectral range between 400 and 700nm and is classified as non-harmful radiation according to experts. About 40% of the sun’s rays reaching the earth are visible light. Despite the omnipresent irradiation by visible light outdoors, only a few studies have dealt with the effects on the skin to date. VL is may cause various skin diseases as well as phototoxic and photoallergic skin reactions.[13]

For the cosmetics industry, a specific range of visible light is of great importance as contact cannot be avoided. Blue light has a wavelength of 400 to 500nm and is also called high-energy visible light. Most blue light radiation is generated by the sun, but we are also exposed to it due to the increased use of digital screens and artificial light.[14, 15] Similar to UV radiation, blue light is capable of generating ROS in the skin, causing significant damage. Unlike UV light, blue light has longer wavelengths and less energy, which allows it to penetrate deeper into the skin layers and cause DNA damage.[16, 17] The main problem with blue light irradiation is ROS formation, which, as already mentioned, can lead to further negative effects. For example, individuals with darker skin types are more likely to react to increased visible light irradiation with hyperpigmentation due to the formation of a protein complex that is seen more often in darker skin types and generates the melanogenesis enzymes tyrosinase and dopachrome tautomerism.[18, 19] When it comes to oxidative stress caused by blue light, flavins and pigments in the skin are the most important photosensitisers. Furthermore, there is evidence that mitochondrial flavin and cytochrome proteins are degraded by blue light.[20] Consequently, the flavins produce superoxide (O2-) when exposed to blue light, an extremely reactive anion radical and major free radical.[21, 22] However, the main reason for blue light damage is probably not the overcoming of cellular antioxidant defences, but the constant production of small amounts of radicals escaping the defence mechanisms.[21]

There are several reasons why a globally effective active ingredient against environmental pollution poses a major challenge. As the range of pollutants and environmental hazards affecting consumers in different parts of the world is incredibly diverse, there are different approaches for the large field of anti-pollution cosmetics. In case you want to specifically counteract radiation, or more precisely, blue light, you must prevent skin damage at the molecular level, which antioxidants are mostly used for.[23, 24] As mentioned above, one of the most promising natural antioxidants is astaxanthin. Due to industry efforts to source natural and sustainable raw materials, according awareness is steadily increasing.

Efficacy of astaxanthin on blue light-stressed human ex vivo skin

Our skin is subjected to daily assaults by external radiation like blue light. Keratinocytes are the dominant cell type in the uppermost layers of the skin which play a special role in skin renewal and the skin’s repair system. Filaggrin is an intermediate filament-associated protein that aids the packing of keratin filaments during terminal differentiation of keratinocytes [25] as well as a major structural protein that appears to function as keratin-aggregating protein. Filaggrin is stored in the granular layer as profilaggrin in an organellar body called keratohyalin granule.[26] During keratinisation, profilaggrin are cut by proteases while the serine threonine residues domains are dephosphorylated to form filaggrin. Hence, the filaggrin degrades into small peptides which act as natural moisturisers and as UV ray absorbers (Figure 4). Under blue light stress, there is a significant decrease in profilaggrin expression in untreated skin explants.[26, 27]

A recent ex vivo study testing an oleoresin containing 5% astaxanthin diluted in jojoba oil addressed the issue of blue light and focused on its use as an anti-pollution ingredient. The objective of this study was to evaluate the efficacy of the red diamond in a model of ex vivo human skin explants under blue light stress. More specifically, profilaggrin expression was evaluated on skin explants maintained ex vivo.

Figure 4: Degradation of profilaggrin.[26]

Material and methods

The human skin explants used were 11mm in diameter with Fitzpatrick skin phototype 3. The skin explants were stored in an incubator at constant conditions of 37°C and 5 volume fraction CO2. A genoskin medium was used as culture medium and Hanks’ Balanced Salt Solution (HBSS) as assay medium. Two different test substances were used in this experiment:

• oleoresin containing 5% astaxanthin diluted in jojoba oil
• 100% jojoba oil (placebo control)

When skin explants were received (day 0), they were cultured for 1 hour before the test compounds were applied topically. Next, the excess of test media was removed with a swab and the surface of the explants rinsed with phosphate-buffered saline (PBS) (day 1). The explants were put in place in the irradiation chamber and irradiate

d in the presence of assay medium until 80 J/cm² (wavelength 427nm) was reached. The irradiation was carried out with 427nm, as there are two different types of lamps. The use of Kessil PR160 for blue light exposure can lead to more stress as it produces shorter wavelength rays compared to other systems (Figure 5).

Figure 5: System of blue light exposure (Kessil PR160).[26]

Each skin explant was then treated again with the test compounds and incubated for 30 minutes, before the excess was removed with a swab. Finally, the explants were recovered (day 2). The following test conditions were examined 3 times each before analysing:

• untreated skin explants
• blue light-stressed skin explants
• 100% Jojoba oil + blue light-stressed skin explants
• 02% oleoresin containing 5% astaxanthin diluted in jojoba oil + blue light-stressed skin explants
• 05% oleoresin containing 5% astaxanthin diluted in jojoba oil + blue light-stressed skin explants
• 1% oleoresin containing 5% astaxanthin diluted in jojoba oil + blue light-stressed skin explants

Profilaggrin immunolabelling was performed as follows. The skin explants were fixed in formaldehyde solution, the fixed samples were then dehydrated in serial ethanol baths with increasing concentration before being embedded in paraffin. Transverse cuts were made with a microtome (5µm thickness, 2 cuts per microscope slide, 1 microscope slide per skin explant) and stored at room temperature for the analysis. The slides were deparaffinised and incubated at 95°C in an unmasking solution to optimise antigen-antibody interaction. The slides were cooled at room temperature in the same solution. After saturation with blocking buffer (TBS-Tween-2% BSA), the slides were incubated overnight with the primary antibody solution directed against the profilaggrin marker. After washing, binding sites recognised by the primary antibody were detected with a fluorescent antibody (GAM-568). The slides were mounted with ProLong^TM containing colour (DAPI) to stain the cell nuclei.

The slides were observed with a ZEISS 710 confocal microscope. The images were taken and processed with the ZEN software (lens x20) by ZEISS (Figure 6). Three images were taken per replicate (9 images per condition). For each marker, fluorescence intensity was measured using ImageJ software. Profilaggrin expression was quantified by measuring fluorescence intensity normalised to epidermal area. The raw data was processed and analysed using Microsoft Excel.

Figure 6: Profilaggrin expression as described.[26]

Results

Blue light stress in ex vivo human skin led to considerable decrease in profilaggrin expression (Figure 7). On the contrary, the use of 0.02% oleoresin containing 5% astaxanthin diluted in jojoba oil already resulted in an increase of 11% in profilaggrin expression. Using a concentration of 0.05%, the profilaggrin expression increased by 12%. The tested 0.1% oleoresin containing 5% astaxanthin diluted in jojoba oil improved the profilaggrin expression by 15%. The trial with jojoba oil (placebo) had no effect on the profilaggrin expression.[26]

Figure 7: Profilaggrin expression under blue light stress.[26]

Conclusion

Anti-pollution is more than just a trend; therefore, the demand for these cosmetic products is increasing all over the world. The cosmetics industry is also looking for new ways to protect our skin against harmful influences. As a result, the industry is very innovative and has already come up with a number of ways to combat pollution. With the focus on sustainable products, efficient and green active ingredients are also becoming more and more relevant. Astaxanthin has been known as an extremely powerful ingredient in nutritional supplements for many years. However, a new study shows that even at very low concentrations, astaxanthin-containing cosmetic raw materials offer good protection against the negative environmental effects of excessive blue light irradiation when applied preventively and curatively. Further studies on this topic will be carried out to obtain more reliable data . Due to such promising studies, astaxanthin is expected to become even more important in the cosmetics world over the coming years, and it will certainly also be of interest to a large number of cosmetics brands.

References

[1] Pitman, S. Euromonitor: The Evolution of AntiPollution in Europe and North America: Part I; Cosmetics Design USA.com; William Reed Business Media SAS: West Sussex, UK, 2017.

[2] Spencer, N. What Does Pollution Mean for Your Skin; Cosmetics Design-Asia.com; William Reed Business Media SAS: West Sussex, UK, 2016.

[3] Krutman, J.; Liu, W.; Li, L.; Pan, X.; Crawford, M.; Sore, G.; Seite, S. Pollution and skin: From epidemiological and mechanistic studies to clinical implications. J. Dermatol. Sci. 2014, 76, 163–168.

[4] Juliano C., Magrini G.A. Cosmetic Functional Ingredients from Botanical Sources for Anti-Pollution Skincare Products. Cosmetics. 2018; 5(1):19. https://doi.org/10.3390/cosmetics5010019

[5] Ambati, R.R. et al. Astaxanthin: Sources, extraction, stability, biological activities and its commercial applications – A review, Marine Drugs, 12(1), 2014; 128–152.

[6] Macaela, M. How Your Phone’s Blue Light Could Be Damaging Your Skin, According to Derms. Jul 14, 2020, https://www.allure.com/story/blue-light-phone-skin-effects [accessed: 01 Sept., 2022].

[7] Valacchi, G., Sticozzi, C., Pecorelli, A., Cervellati, F., Cervellati, C., and Maioli, E. Cutaneous responses to environmental stressors. Ann N Y Acad Sci. 2012; 1271:75-81.

[8] Pinnell SR. Cutaneous photodamage, oxidative stress, and topical antioxidant protection. J Am Acad Dermatol. 2003; 48:1–19.

[9] Zhou, X., Cao, Q., Orfila, C., Zhao, J., and Zhang, L. Systematic review and meta-analysis on the effects of astaxanthin on human skin ageing, Nutrients, vol. 13, no. 9, pp. 1–18, 2021, doi:10.3390/nu13092917

[10] McDaniel, D., Farris, P., and Valacchi, G. Atmospheric skin aging—Contributors and inhibitors. J Cosmet Dermatol. 2018; 17: 124–137. https://doi.org/10.1111/jocd.12518

[11] Cho, S., Shin, M.H., Kim, Y.K. et al. Effects of infrared radiation and heat on human skin aging in vivo. J Investg Dmermatol 2009; 14:15–19

[12] Sklar, L.R., Almutawa, F., Lim, H.W., and Hamzavi, I. Effects of ultraviolet radiation, visible light, and infrared radiation on erythema and pigmentation: a review. Photochem Photobiol Sci. 2013; 12:54–64.

[13] Kollias, N. and Bager, A. An experimental study of the changes in pigmentation in human skin in vivo with visible and near infrared light. Photochem Photobiol. 1984; 39:651–659.

[14] Schiavi, C. and Giannaccare, G. Eye and Pollution. In: Capello, F. and Gaddi, A.V. (eds). Clinical handbook of air pollution-related diseases. Cham, Switzerland: Springer International Publishing; 2018:341–351.

[15] Zou, L. and Dai, J. Blue light and eye health. Zhonghua Yan Ke Za Zhi. 2015; 51(1):65–69.

[16] Pissavini, M., Pujos M., and Doucet, O. Total exposure: the future of sun care is full light protection. Cosmet Toiletries. 2018; 133(4):26–34.

[17] Opländer, C., Hidding, S., Werners, F.B., Born, M., Pallua, N., and Suschek, C.V. Effects of blue light irradiation on human dermal fibroblasts. J Photochem Photobiol B. 2011; 103(2):118–125.

[18] Regazzetti, C., Sormani, L., Debayle, D. et al. Melanocytes sense blue light and regulate pigmentation through Opsin-3. J Invest Dermatol. 2018; 138(1):171–178.

[19] Duteil, L., Cardot-Leccia, N., Queille-Roussel, C. et al. Differences in visible light-induced pigmentation according to wavelengths: a clinical and histological study in comparison with UVB exposure. Pigment Cell Melanoma Res. 2014; 27(5):822–826.

[20] del Olmo-Aguado, S., Núñez-Álvarez, C., and Osborne, N.N. Blue Light Action on Mitochondria Leads to Cell Death by Necroptosis. Neurochem Res 41, 2324–2335 (2016). https://doi.org/10.1007/s11064-016-1946-5

[21] Nakashima, Y., Ohta, S., and Wolf, A.M. Blue light-induced oxidative stress in live skin. Free Radic Biol Med. 2017; 108:300–310.

[22] Pimenta, F.M., Jensen, R.L., Breitenbach, T., Etzerodt, M., and Ogilby, P.R.. Oxygen-dependent photochemistry and photophysics of “miniSOG,” a protein-encased flavin. Photochem Photobiol. 2013; 89(5):1116–1126.

[23] Pandel Mikuš, R., Poljšak, B., Godic, A., Dahmane, R., 2013. Skin Photoaging and the Role of Antioxidants in Its Prevention. https://www.doi.org/10.1155/2013/930164

[24] Pitman, S. Antipollution Is Massive but Complicated – Here’s Why; Cosmetics Design-Asia.com; William Reed Business Media SAS: West Sussex, UK, 2017.

[25] Piipponen, M., Li, D., and Landén, N.X. The Immune Functions of Keratinocytes in Skin Wound Healing. Int J Mol Sci. 2020 Nov. 20; 21(22):8790. doi: 10.3390/ijms21228790. PMID: 33233704; PMCID: PMC7699912.

[26] QIMA Synelvia – Labège laboratories. Evaluation of the efficacy of AstaCos® on blue light-stressed human ex vivo skin. 2022.

[27] Kuechle, M.K., Presland, R.B., Lewis, S.P., Fleckman, P., and Dale, B.A. Inducible expression of filaggrin increases keratinocyte susceptibility to apoptotic cell death. Cell Death Differ. 2000 Jun; 7(6):566–573. doi: 10.1038/sj.cdd.4400687. PMID: 10822280.

Der Beitrag Astaxanthin – the perfect choice for anti-pollution products erschien zuerst auf BDI-BioLife Science.

BDI-BioLife Science is a young company that focuses on the development of innovative and sustainable algae-based ingredients. For the past 15 years, the company has been dedicated to the cultivation of the astaxanthin-rich microalgae Haematococcus pluvialis. Constant improvements have led to a unique cultivation system that was developed in-house. Today, the company produces astaxanthin in Styria – the “green heart” of Austria – and offers scientifically researched raw materials for a wide range of applications in the food supplement and cosmetic industry. Astaxanthin is the strongest natural antioxidant that can protect the human organism through oral and topical application due to its special molecular structure. BDI-BioLife Science has developed a special COSMOS-certified and NATRUE-approved active ingredient to include this unique antioxidant in cosmetic formulations. ASTACOS® OL50 is a vegan, animal testing-free ingredient, derived from the microalga Haematococcus pluvialis, containing 5% of natural astaxanthin.

Katharina Müller, former Head of Product Development and Product Management at BDI-BioLife Science, will outline the advantages of ASTACOS® OL50 and explain how the ingredient is incorporated into formulations.

There are so many different types of antioxidants – why are you convinced of astaxanthin respectively ASTACOS®  OL50 as a must-have in cosmetics?

ASTACOS®  OL50 includes the strongest natural antioxidant, astaxanthin. Low dosages (0.01% to 0.1% of ASTACOS® OL50) of this active ingredient in a formulation have achieved really great results in various studies, and that effect truly convinced me. The naturalness of the raw material in combination with the scientific approach to production fascinates me. Besides the Cosmos certification and Natrue approval, the fact that ASTACOS® OL50 is vegan is also worth mentioning. Its enormous antioxidative potential which is based on the special structure of lipophilic and hydrophilic end groups in combination with the long-chain basic structure of astaxanthin deserves special attention. I also like the fact that you can see the activity of ASTACOS® OL50 in the colour of the product. The overallASTACOS® OL50 package is completed by in vivo and in vitro studies which highlight the unique effect.

Which claims of ASTACOS®  OL50 would you particularly want to mark out, and in which formulations do you see the greatest potential for the ingredient?

Astaxanthin has great antioxidant potential when it comes to neutralising ROS. Through this improved biological cell protection, harmful oxidation processes in the cells are stopped. Thus, long-term damage to the skin, such as wrinkles, can be minimised. Therefore, when it comes to anti-ageing applications, we consider particularly astaxanthin as antioxidant. As natural and highly effective raw materials are currently trending, the use in natural products is recommended. Of course, it also makes sense to use ASTACOS® OL50 in case of increased stress situations, for example after intensive sun radiation. Therefore, the use of ASTACOS® OL50 in sun care products is also recommended.

You mentioned the colour in the finished product which is created by adding ASTACOS® OL50. Could you tell us about the photostability of the product? Have tests already been performed on this matter?

In general, it should be pointed out that ASTACOS® OL50, in contrast to other carotenoids, has a very good colour stability. I personally have some finished product samples containing ASTACOS® OL50 in my office that still show excellent colour after several months. Indeed, BDI-BioLife Science is aware of the colour topic and has, therefore, initiated an accelerated weathering test in which two other natural dyes (beetroot and carmine) and ASTACOS® OL50 were compared. In this test, each sample was benchmarked against its own ref erence, and ASTACOS® was the only product that had not lost colour after 15 hours of strong irradiation. In addition, finished frame formulations were also tested, and the result was that no degradation occurred regarding colour or smell.

Figure 1: ASTACOS® FACE Astaxanthin Refresh (form. asta2PHASE) after 48h of excessive irradiation at 50w/m² in the UV/VIS irradiation chamber (Opsytec Dr. Gröbel GmbH) leads to no changes.

Due to the mechanism of action as well as the colour, ASTACOS® OL50 can definitely be considered a special raw material. Do you have any other recommendations for the operator?

ASTACOS® OL50 is a fat-soluble extract from the alga H. pluvialis, but there are also natural ways to dissolve the active ingredient in the water phase. With the addition of solubilisers, the oil phase has to be treated very carefully in terms of stability and oxidation. I will give you a piece of advice for using ASTACOS® OL50: an acidic pH proves extremely beneficial for high product stability and creates a balanced formulation for the skin.

Figure 2: ASTACOS® OL50, oleoresin with an astaxanthin content of 5%.

As an Austrian company, BDI-BioLife Science cultivates microalgae in Styria and is the largest central European producer of astaxanthin. What advantage do you see in European high-tech production?

Production in the heart of Europe offers many benefits: on the one hand, a “made in Austria” label is recognised worldwide. On the other hand, there is also the question of supply security, especially since the beginning of the COVID-19 pandemic. All-year delivery is ensured with BDI as a partner because of the company’s long-term plant expertise, while the special know-how influences the product quality. As mentioned above, the quality of ASTACOS® OL50 has been proven by numerous certificates.

Statement by Roman Ott, Head of Application Technology at RAHN Group:

“It continually surprises me how secrets of nature with their impressive efficacy can be successfully transferred to cosmetics.”

Der Beitrag Interview: ASTACOS® OL50 – formulating with the red diamond erschien zuerst auf BDI-BioLife Science.